24th Oct, 2018
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Cancer is a systemic disease with tumors as a local manifestation of the disease. Once cancer occurs in a person, cancerous cells will be found in the body. Surgical removal of tumors in no way implies that one is cured of cancer. For example, breast cancer can relapse even if the original tumors were removed.Like hypertension and diabetes, cancer is a chronic disease. The disease may take a few years to manifest itself - from its occurrence until the emergence of tumors. In some cases, cancer cells may exist in a stage of ....
"SAVE YOUR BREASTS!": Cryosurgical Ablation Makes Early-stage Breast Cancer Free From Open Surgery_events_fuda news_Fuda Cancer Hospital Guangzhou_Cancer Treatment China_Tumor Technology_广州复大肿瘤医院_癌症治疗_微创治疗_癌症疗法
"SAVE YOUR BREASTS!": Cryosurgical Ablation Makes Early-stage Breast Cancer Free From Open Surgery
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It is known that breast cancer has become “the first killer” of women nowadays.

Top-level medical institutions including Cornell University, Mayo Clinic, and MD Anderson Cancer Center have recently published some papers in Annals of Surgical Oncology, an official journal of American Society of Therapeutic Radiology and Oncology (ASTRO) and the Society of Surgical Oncology (SSO), which indicated that “cryosurgical ablation should be deemed as one of alternatives available in treatment of early-stage breast cancer apart from conventional surgery”. Dr. Mu Feng, Vice President of Guangzhou Fuda Cancer Hospital affiliated to Jinan University noted yesterday, “It is undoubtedly that cryosurgical ablation provides early-stage breast cancer patients with one more effective option”.


As indicated in the last August’s stage-II research report, “cryosurgical ablation is believed as an alternative available for many early-stage breast cancer patients besides conventional surgery”. (This report was formally released in Annals of Surgical Oncology, an official journal of American Society of Therapeutic Radiology and Oncology (ASTRO) and Surgical Society of Oncology (SSO) by American College of Surgeons Oncology Group (ACOSOG), consisting of New York Presbyterian Hospital, Cornell University, Mayo Clinic, University of South Florida , Main Line Health Center,  University Of Texas MD Anderson Cancer Center, Providence Saint Joseph Medical Center, University of Michigan Ann Arbor, Henry Ford Hospital, Bridgeport Hospital, Genesys Regional Medical Center, Bellingham Breast Oncology Center, Indiana University, Lehigh Valley Hospital, Pennsylvania State University, University of Southern California, Duke University).

Destroy cancer cells by cycles of freezing-thawing procedure

Cryosurgical ablation, also termed as argon-helium cryosurgery, is a novel technique for treatment of cancer with minimal invasion. With increasingly prevalent application of mini-invasive therapy in cancer treatment, some U.S. experts have noted that cryosurgical ablation is believed as an effective way in treating early-stage breast cancer currently.


Cryosurgical Ablation in Process

Using imaging-guided techniques (B Ultrasound or CT), cryo-probes are precisely inserted into tumors to lower the temperature of the targeted area -100℃ or lower (it is believed that death of tumor tissues would be certain in such a temperature) by releasing argon from apparatus connected to probes, which lasts for more than 10 minutes. After finishing the freezing procedure, argon delivery would be stopped and replaced by helium, a heat source that could thaw the "ice-ball" formed on the tumor tissues. By cycles of freezing-thawing ablation, cancer cells would be definitely destroyed.

Cryosurgical ablation that can be conducted under local anesthesia has been widely applied in treating liver cancer, lung cancer and kidney cancer for many years. And it is worth noting that this technique could also be used in treatment of noncancerous breast tumor such as fibroma and early-stage breast cancer (the main conventional therapeutic methods are radiotherapy and surgeries).


As shown in the phase-II non-randomized clinical trial performed by American researchers, there are 86 of 99 cases of cancer patients (97 breast cancer patients) being collected from 19 medical centers at home for data analysis and 92% of them have proved to be successfully treated by cryosurgical ablation, with 100% of post-procure tumors less than 1cm in size. Within 28 days after cryosurgical ablation, patients’ main tumor has been ablated completely.  This trial marks that cryosurgical ablation has been firstly adopted in treating early-stage breast cancer on multi-center study.


Dr. Simmons, Director of Breast Surgery and Professor of Oncological Surgery, Cornell University Medical Center once noted, “Cryosurgical ablation seems to provide with a unique but effective alternative for breast cancer treatment. With advancement of further researches, we have every reason to believe that there would and must be a promising future of this technique soon after.


It is statistically shown that there are a total of 500,000 people dying of breast cancer each year worldwide. According to the 2015 China’s cancer statistics, there are totally 69,500 females dying of breast cancer in China each year. In UK, nearly 39,000 breast cancer patients are conducted lumpectomy every year as recorded and about 1/5 of them require for further operations due to failure of cancer cells clearance.


Cryosurgical Ablation Has the Advantage of Less Injury, Cost-saving, Coverage of Medicare Compared with Conventional Surgery, Radiotherapy and Chemotherapy



With release of helium gas by cryo-probes inserted, the temperature around probe tips would fall below -140℃, during which the targeted tumor would certainly end in death within a short time. Then by changing to argon gas delivery, the temperature around probe tips would resume to around 20℃, which effectively keeps away from unnecessary damage to the surrounding organs and tissues. This technology requiring for neither anesthesia nor open surgery, is quite fit for clinical treatment for solid tumors like liver cancer, lung cancer, prostate cancer, soft-tissue tumors.


Cryosurgery has been approved by the United States’ Food & Drug Administration (FDA) since 1998 and China’s FDA since 1999. The medical team led by Dr. Xu Kecheng, the Chief President of Guangzhou Fuda Cancer Hospital affiliated to Jinan University School of Medicine has firstly introduced this technique and associated equipments in China mainland in 2001.


Dr. Mu Feng, Vice-President of FUDA introduced, “It is believed that radical operation remains to be the preferred approach in treating breast cancer as of now, and that cryosurgical ablation could effectively treat small or early-stage breast cancer (less than 1.5cm in diameter or carcinoma in situ without lymph node metastasis) with the same curative effect as that of operation.


Cryosurgical ablation, as a physical therapy, has the advantage of little side effects, short treatment time, less expenditure, etc. In general, patient merely requires for one treatment in each visit and could discharge after 2-3 days’ observation.


It is understood that cryosurgical ablation has been listed into National Health Insurance Directory and each treatment costs only RMB20, 000. In comparison with conventional cancer treatments, cryosurgical ablation usually destroys tumors by two sessions of freezing-thawing procedure, leaving with minimal trauma only. And compared with surgical treatments, this technique could successfully keep organ integrity or at least make for little influence to organic function. It is also worth noting that cryoablation procedure could enhance human’s anti-cancer immunocompetence, which means that some metastases are even possible to become smaller or eradiated by immune system after cryosurgery. Doctors from a hospital of Beijing once noted, “Current study has shown that cryosurgical ablation under low-dosage local anesthesia is definitely comparable with conventional open surgery in treatment of early-stage liver cancer, with almost the same five-year survival rate but significantly less intraoperative injuries. 


Cryosurgical ablation is currently adopted by FUDA in treating malignant tumor of solid organs including liver, pancreas, lung, prostate, and kidney. As recorded, more than 10,000 cases of percutaneous cryosurgery have been successfully performed in FUDA so far, with over 80% of effective rate, and nearly 200 cryosurgery-related papers including 46 SCI papers, as well as academic monographs like Cryosurgery for Cancer (Chinese version) and Modern Cryosurgery for Cancer have been published by FUDA. It is undoubtedly that FUDA’ achievements in the field of cryotherapy come out top not only in China but also world. 


In the 2013 17th World Congress of the International Society of Cryosurgery (ISC), Prof. Xu Kecheng from Guangzhou Fuda Cancer Hospital was elected as the President of ISC. And Prof. Niu Lizhi, the Executive President of FUDA was elected as the Vice President of ISC in the 18th World Congress of Cryosurgery.


FUDA has succeeded in treating a number of cases of breast cancer patients by using cryosurgical ablation. In Sep. 2016, Prof. Xu Kecheng, the Chief President of FUDA and then-President of ISC, paid a special visit to Indonesia for his three old breast cancer patients who once underwent cryosurgical ablation in FUDA. After knowing their rehabilitation conditions, Prof. Xu could hardly curb the excitement in his mind because they three who were once diagnosed with giant tumors and metastases has evidently got an effective condition control and successfully survived for over eight years after cryosurgical ablation.

A Distinguished Guest from Britain Sought for Medical Help in FUDA


Before Mar. 2014, there came a special female patient in FUDA. She, a bilateral breasts cancer patient from Britain, came all the way to FUDA for cryosurgical ablation. 

After examined, the surgical team led by Prof. Niu Lizhi conducted a percutaneous puncture cryosurgery for this lady’s breast cancers two days later. The whole procedure underwent in the status of deep sleep from left side to right side. On the process, three cryo-probes were inserted into each breast respectively and then the temperature of probe tip instantly reduced to -160℃, which lasted for 10mins, and after freezing-procedure, the temperature of targeted area was raised to 40℃. Two cycles of freezing-thawing ablation were administrated.

One week later, this madam’s private assistant called on the secretary of President Xu and said that she would like to make a donation to FUDA on further research of cryosurgical ablation and salvation of impoverished patients.

At that night, Prof. Xu had a meeting with this “noble” madam, a tall lady with smooth white hairs peculiar to Westerners and a pair of green eyes glittering below long cilia. She walked to Prof. Xu with light but steady steps. They shook hands and greeted warmly each other.

In this meeting, she proposed to establish Elizabeth Cancer Foundation with her balance at FUDA and said she would continue to transfer money to the foundation thereafter. She spoke highly of FUDA’s cryosurgical ablation which makes both painless treatment and breast conservation possible.  She said with excitement, “I really would like to call for doctors in our country to realize that how importantly breasts mean to a woman!” When learned that President Xi serves as the President of International Society of Cryosurgery, she said, “It is our sincere hope that you could help us train doctors in this field.”

Prof. Xu once asked, “What drives you travel thousands of miles to China for treatment?” Her answer was quite simple, that is, “SAVE MY BREASTS”. When asking why she refused to receive chemotherapy, a conventional treatment after all, she said, “According to my private doctors’ research, there has been no evidence that chemotherapy would make me live longer, but…” She touched her beautiful white hairs gently and said to Prof. Xu with a big smile, “I couldn’t bear to lose my hairs. They have been with me for a lifetime!”

In the summer of 2016, this madam happily had her return visit at FUDA again…



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